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Raffaele Pilla: A Neuron-Specific Protein Found in Skeletal Muscle : New Frontiers for Gap-43

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Growth Associated Protein 43 (GAP-43), isolated from rat brain and considered a neuronal marker, is involved in neurite branching, cytoskeleton remodelling, neuronal development and protection. However, GAP-43 mRNA was found in embryonic chicken cells positive to meromyosin, as well as in human satellite cells, myoblasts and myotubes deriving from healthy or dystrophic muscles. Despite these findings, there is no clear evidence about its localization or relationship with other muscle proteins. The aim of this study was to investigate GAP-43 protein expression and localization in C2C12 cells and mice skeletal muscle fibers, using immunoblot and immunofluorescence protocols for confocal mycroscopy. Immunoblot analyses show the presence of GAP-43 in C2C12 cell homogenates as well as in mature muscle fibers. Immunofluorescent images reveal that the protein is localized nearby the external nuclear membranes in C2C12 myoblasts, while in C2C12 myotubes, it has been detected on muscular streaks, in a regular double strand pattern. This localization has been found also in Extensor Digitorum Longus fibers isolated from 1 week, 1 and 24 months old mice. In isolated adult mouse fibers, GAP-43 localization appears to be in relationship with crucial proteins such as triadin, alfa-actinin, RyR, DHPR, as well as mitochondria. In addition, cross-specimen analyses on skeletal muscle cells and mature fibers from Xenopus Laevis (amphibian), rat and human were performed, in order to interpret the results from an evolutionary point of view. In conclusion, these preliminary data confirm the presence of GAP-43 in all the analyzed skeletal muscles, and its localization supports the hypothesis of a possible new functional role in the muscle excitation-contraction coupling process.

The commercial airline industry is one of the most volatile, dog-eat-dog enterprises in the world, and in the late 1990s, Europe's Airbus overtook America's Boeing as the preeminent aircraft manufacturer. However, Airbus quickly succumbed to the same complacency it once challenged, and Boeing regained its precarious place on top. Now, after years of heated battle and mismanagement, both companies face the challenge of serving burgeoning Asian markets and stiff competition from China and Japan. Combining insider knowledge with vivid prose and insight, John A Neuron-Specific Protein Found in Skeletal Muscle : New Frontiers for Gap-43 free ebook Newhouse delivers a riveting story of these two titans of the sky and their struggles to stay in the air. TV chef, dragon slayer and bestselling author Levi Roots brings carnival to the kitchen with his hot'n'spicy Caribbean cookbook. After winning over the business minds of The Dragon's Den with little more than a song and a smile, entrepreneur Levi Roots has since sold more than one million bottles of his delicious Reggae Reggae Sauce and now he has his very own cookbook! Levi Roots' Reggae Reggae Cookbook brings the excitement and vitality of Caribbean flavours to your own cooking. An eclectic and colourful range of recipes from simple dishes for students to fantastic feasts for friends are all accompanied by heart-warming anecdotes in Levi's incomparable tell-it-like-it-is style. This bright and colourful book brings together influences as diverse as Jamaican folk tales, Notting Hill Carnival and the music of Bob Marley to create family-friendly food with that famous jerk kick. Levi Roots' Reggae Reggae Cookbook will surely add a funky beat to what you eat! Levi Roots' Reggae Reggae Cookbook features more than 80 simple and exciting recipes such as Mash-Up Eggs, Salmon St Jago de la Vega , Guinness Punch, Rum Cake and Sweet Potato Pudding.

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Andreas Kitzmann: Saved from Oblivion : Documenting the Daily from Diaries to Web Cams

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What lies behind our need to rigorously document the thoughts, deeds, images, and sounds of everyday life? And more curiously, why would anyone want to spend time going over such material? At any given point someone is using a pen, a camera, a web cam, or a computer to document with varying degrees of detail, personal thoughts, observations, or glimpses of private space and life. And for each of these, there is usually at least one person reading, watching, and even responding. Saved from Oblivion is a comparative analysis of how individuals have used various media technologies to document their everyday lives. More specifically, this book focuses on the major forms of self-documentation that have been in use since the late nineteenth century and covers traditional diaries, snapshot photography, home movies/videos, and web-based media such as web cams and online diaries or journals.

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Clarissa Dickson Wright: A History of English Food

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In this major new history of English food, Clarissa Dickson Wright takes the reader on a journey from the time of the Second Crusade and the feasts of medieval kings to the cuisine - both good and bad - of the present day. She looks at the shifting influences on the national diet as new ideas and ingredients have arrived, and as immigrant communities have made their contribution to the life of the country. She evokes lost worlds of open fires and ice houses, of constant pickling and preserving, and of manchet loaves and curly-coated pigs. And she tells the stories of the chefs, cookery book writers, gourmets and gluttons who have shaped public taste, from the salad-loving Catherine of Aragon to the foodies of today. Above all, she gives a vivid sense of what it was like to sit down to the meals of previous ages, whether an eighteenth-century labourer's breakfast or a twelve-course Victorian banquet or a lunch out during the Second World War. Insightful and entertaining by turns, this is a magnificent tour of nearly a thousand years of English cuisine, peppered with surprises and seasoned with Clarissa Dickson Wright's characteristic wit.

Peter Purves is known to generations as one of the all-time great Blue Peter presenters, but this came after an acting career which he's returning to here to play both the Doctor and 1960s A History of English Food download book companion Steven Taylor. Maureen O'Brien - 1960s Doctor Who companion Vicki - is also a novelist whose works include Mask of Betrayal (1998), Every Step You Take (2004) and Deadly Reflection (2007). Guest star Olivia Poulet is well known for her role as Emma Messinger in The Thick of It. She's also recently played Emma Peel in Big Finish's revival of The Avengers - Steed & Mrs Peel. CAST: Maureen O'Brien (Vicki), Peter Purves (Steven Taylor/The Doctor/Narrator), Mark Frost (Niccolo Machiavelli), Jamie Ballard (Guiliano de Medici), Robert Hands (Pope Leo X), Olivia Poulet (Carla), Joe Bor (Guard Captain). * In the spirit of Fables: 1001 Nights of Snowfall and Fables: Werewolves of the Heartland comes the first ever original graphic novel from the pages of #1 New York Times bestselling writer Bill Willingham's Fairest.

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Robert Zaretsky: Albert Camus: Elements of a Life

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"Like many others of my generation, I first read Camus in high school. I carried him in my backpack while traveling across Europe, I carried him into (and out of) relationships, and I carried him into (and out of) difficult periods of my life. More recently, I have carried him into university classes that I have taught, coming out of them with a renewed appreciation of his art. To be sure, my idea of Camus thirty years ago scarcely resembles my idea of him today. While my admiration and attachment to his writings remain as great as they were long ago, the reasons are more complicated and critical." Robert ZaretskyOn October 16, 1957, Albert Camus was dining in a small restaurant on Paris's Left Bank when a waiter approached him with news: the radio had just announced that Camus had won the Nobel Prize for Literature. Camus insisted that a mistake had been made and that others were far more deserving of the honor than he. Yet Camus was already recognized around the world as the voice of a generation a status he had achieved with dizzying speed. He published his first novel, The Stranger, in 1942 and emerged from the war as the spokesperson for the Resistance and, although he consistently rejected the label, for existentialism. Subsequent works of fiction (including the novels The Plague and The Fall), philosophy (notably, The Myth of Sisyphus and The Rebel), drama, and social criticism secured his literary and intellectual reputation. And then on January 4, 1960, three years after accepting the Nobel Prize, he was killed in a car accident.In a book distinguished by clarity and passion, Robert Zaretsky considers why Albert Camus mattered in his own lifetime and continues to matter today, focusing on key moments that shaped Camus's development as a writer, a public intellectual, and a man. Each chapter is devoted to a specific event: Camus's visit to Kabylia in 1939 to report on the conditions of the local Berber tribes; his decision in 1945 to sign a petition to commute the death sentence of collaborationist writer Robert Brasillach; his famous quarrel with Jean-Paul Sartre in 1952 over the nature of communism; and his silence about the war in Algeria in 1956. Both engaged and engaging, Albert Camus: Elements of a Life is a searching companion to a profoundly moral and lucid writer whose works provide a guide for those perplexed by the absurdity of the human condition and the world's resistance to meaning."

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Steven Lukes: Power

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Steven Lukes' Power: A Radical View is a seminal work still widely used some 30 years after publication. The second edition includes the complete original text alongside two major new essays. One assesses the main debates about how to conceptualize and study power, including the influential contributions of Michel Foucault. The other reconsiders Steven Lukes' own views in light of these debates and of criticisms of his original argument. With a new introduction and bibliographical essay, this book will consolidate its reputation as a classic work and a major reference point within social and political theory.

'...perfect not only for thoroughly understanding the basis of pathology, but also for looking up specific conditions' - ("Medical Student Review"). One of the best-selling medical textbooks of all time, this is a 'who's who' of pathology experts, providing the most dependable, current, and complete coverage of today's essential pathology knowledge. Student-friendly editing and practical organisation make this Power free pdf the ideal way for you to understand pathology. The concealment of income, wealth and profits in tax havens has brought the topic of offshoring into public debate, but as John Urry shows in this important new book offshoring is a much more pervasive feature of contemporary societies. These often secretive activities offshore also involve relations of work, finance, pleasure, waste, energy and security. Powerful and pervasive offshore worlds have been generated, posing huge challenges both for governments and for citizens. This book documents the various patterns of offshoring D of the economy, sociability, politics and the environment. In each case, offshoring generates new patterns of power, reduces the responsibilities of the powerful 'offshore class', and limits the conditions for democratic governance. Offshore, out of sight, over the horizon are some of the troubling processes and metaphors by which much life has been rendered opaque and dependent upon secrets and lies. By analysing these patterns and processes, Urry sheds fresh light on the hidden worlds of offshoring and exposes the dark side of globalization.

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April Chorba: Pom-Pom Puppies

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Turn plain yarn into perfectly precious pups with Pom-Pom Puppies. Using the amazing custom tool, young crafters can wrap, snap and snip their way to perfect pom-poms. Follow the simple number code instructions to clip the pom-poms into shaggy-pups by gluing together and adding noses, ears and eyes to create pups worthy of Best in Show. Pom-Pom Puppies shows you how to create 10 breeds of dog including a beagle, poodle and pug.

Robots may one day rule the world, but what is a robot-ruled Earth like? Many think the first truly smart robots will be brain emulations or ems. Scan a human brain, then run a model with the same connections on a fast computer, and you have a robot brain, but recognizably human. Train an em to do some job and copy it a million times: an army of workers is at your disposal. When they can be made cheaply, within perhaps a century, ems will displace humans in most jobs. In this new economic era, the world economy may double in size every few weeks. Some say we can't know the future, especially following such a disruptive new technology, Pom-Pom Puppies free pdf but Professor Robin Hanson sets out to prove them wrong. Applying decades of expertise in physics, computer science, and economics, he uses standard theories to paint a detailed picture of a world dominated by ems. While human lives don't change greatly in the em era, em lives are as different from ours as our lives are from those of our farmer and forager ancestors. Ems make us question common assumptions of moral progress, because they reject many of the values we hold dear.

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Grimm Brothers,Margaret Hunt,Gris Grimly: Gris Grimly's Tales from the Brothers Grimm

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The Brothers Grimm's fairy tales are brought to life for a new generation of readers in their original, uncut form by the modern master of gothic horror, Gris Grimly. Grimm. The name alone is enough to call to mind any number of the timeless fairy tales collected by brothers Jacob and Wilhelm in the early nineteenth century. These folktales have been told and retold in many forms for over two centuries, and while the particular mix of fantasy, adventure, and wonder that defined their seven-volume collection has endured, the terror, violence, and darkness of the original stories has often been lost in translation. Enter Gris Grimly, who has faithfully reproduced the original text of a selection of tales and adorned them with his own inimitable artwork. The result is a Grimm collection unlike any other, set in a world that is whimsically sinister, darkly vivid, and completely unforgettable.

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Ed Emberley: Ed Emberley's Complete Funprint Drawing Book

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This two-in-one edition of two of Emberley's popular titles--Ed Emberley's Fingerprint Drawing Book and Ed Emberley's Great Thumbprint Drawing Book--shows youngsters step by step how to make their fingerprints and thumbprints into works of art. Full color.

Can Kazama resist the girls' bizarre charms and return to some semblance of a normal, everyday life...or is it "game over" for our hapless hero? In the town of Waterby on Fire Island, the rhythms and rituals of summer are sacrosanct: the ceremonial arrivals and departures by ferry; yacht club dinners with terrible food and breathtaking views; the virtual decree against shoes; and the generational parade of sandy, sun-bleached kids, running, swimming, squealing, and coming of age on the beach. Praise for the 1st edition: "This book is a must have for any midwife, particularly those working in the community, clinics and in high-risk areas...This book is an extremely useful reference tool." (MIDIRS Midwifery Digest) "The important facts are laid out concisely, primarily focusing on management, using evidence based guidelines for best midwifery practice." (RCGP Journal) Medical Disorders in Pregnancy: A Guide for Midwives, 2nd edition clearly outlines existing and pre-existing conditions which women can experience during pregnancy. This comprehensive and practical handbook identifies issues for pre-conception care, defines the condition, explores possible complications, outlines recommended treatment and emphasizes specific midwifery care. This fully revised and updated edition of Medical Disorders in Pregnancy: A Guide for Midwives Ed Emberley's Complete Funprint Drawing Book ebook pdf builds on the success of the first edition by covering more subjects. It includes physiology, more illustrations and algorithms and its accessible reference-style text enables information to be quickly and easily found.

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Adam Blade: Kama the Faceless Beast

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Tom's most dangerous Quest ever is heading towards an explosive climax! He must confront Kama the Faceless Beast, an old foe of his father's. Will Tom prevail?

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